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Careers at Kapoose Creek Bio

Develop the next generation of medicines

Open Positions

Working at Kapoose Creek Bio

Kapoose Creek Bio is developing a new approach to drug discovery—one grounded in natural chemistry and accelerated by computation.

We explore the vast diversity of compounds produced by living systems and apply machine learning and advances in OMICs technologies to identify those with therapeutic potential. Our work brings together biology, chemistry, and data science to uncover signals that traditional approaches often miss.

We are a small, focused team working across disciplines, with a shared goal of translating natural insights into meaningful advances in human health.

Interdisciplinary by design

Our work sits at the intersection of computation and experimental science. We collaborate closely across domains.

Driven by evidence

We prioritize scientific rigor, clarity, and reproducibility in everything we do.

Focused and ambitious

We pursue difficult problems with a long-term perspective, aiming to uncover opportunities others overlook.

Open Positions

Neurobiology Lead – Drug Discovery


Scientist to VP level | Full-time

Location: McMaster Innovation Park, Hamilton, ON (On-site)

The Opportunity:
We are seeking an exceptional scientist with deep expertise in neuroscience and neurobiology to help expand our capabilities in complex neural systems and advance our growing pipeline.

This is a rare chance to work at the frontier of natural product drug discovery, contributing both at the bench and, depending on experience, at the level of scientific direction.

This role involves collaborating closely with our interdisciplinary team across microbiology, chemistry, and biology. You will design and apply advanced neural and neurobiological assay systems to evaluate the activity of novel compounds, build mechanistic insight in disease-relevant models, and contribute to targeted therapeutic strategies for neuropsychiatric and neurodegenerative disorders.

This may include work in areas such as:

  • Neuronal cell models
  • Synaptic biology
  • Neuroinflammation
  • Functional modulation of neural circuits

Depending on your experience, this may extend to helping shape experimental and program strategy.

Qualifications & Requirements:

  • PhD or postdoctoral training in neuroscience or a related field
  • Strong experience in neurobiology and in vitro or ex vivo neural model systems
  • Background in neurological disease is preferred
  • Track record of impactful scientific work in academia or industry
  • Experience in phenotypic screening, electrophysiology, high-content imaging, multi-omics, or drug discovery is an asset

Why Kapoose Creek Bio:
We are a dynamic, highly collaborative organization working at the interface of biology, chemistry, and AI, with a shared goal of unlocking new regions of natural chemical space for therapeutic discovery.

If you’re energized by that challenge, we’d love to hear from you. The title and level for this role will be aligned with experience and our existing team structure.

Apply:
Send your CV and cover note to:
careers@kapoosecreekbio.com

While we thank all applicants, only those selected for an interview will be contacted.

Don’t see what you are looking for?

Please reach out to share your background and interests. We are always keen to connect with talented individuals motivated to improve the health of our world.

careers@kapoosecreek.com